A man has been arrested on suspicion of attempted murder after a woman suffered "life-changing injuries" when a car mounted the pavement and struck her.
Humberside Police said the incident happened on Chanterlands Avenue in Hull shortly before 07:30 BST.
A spokesperson said officers had received reports that the woman had been hit by a silver Volkswagen Polo.
A 50-year-old man was arrested at the scene and remained in custody, the spokesperson added.
Detective Inspector Helen Collier said: "I understand an incident of this nature will be concerning to the local community; however, I want to offer my reassurance that from our enquiries carried out so far, we believed this to be an incident between people known to each other."
Passers-by rushed to help the woman after she was struck by the car.
Police have appealed for witnesses, or anyone with dashcam footage, to get in touch via the 101 non-emergency number.
Road closures remain in place between Westbourne Avenue and Marlborough Avenue.
Hull and East Yorkshire on BBC Soundslatest episode of Look North here.